Hsa-mir-182 downregulates RASA1 and suppresses lung squamous cell carcinoma cell proliferation

This work was undertaken to identify the differences in expression of miRNAs, which would predict early-stage non-small cell lung cancer prognosis and recurrence. The results may be helpful to demonstrate one mechanism of lung squamous cancer proliferation.

Lung squamous cell carcinoma specimens were collected at the time of surgery. Microarray of expression of specific miRNAs in lung squamous cell cancer tissue, were assessed by qRT-PCR.

We found that the hsa-mir-182 family are highly expressed in lung squamous cell carcinoma. Paradoxically, our study reveals mir-182 suppresses cell proliferation in vivo. RASA1 is related to cell apoptosis. We further show that mir-182 downregulates RASA1.

We provide first time evidence through tissue microarray and quantitative PCR validation of mir-182 in the expression of lung squamous cell carcinoma. Our data provide a possible mechanism for lung cancer cell proliferation in lung squamous cell cancer and may be helpful in discovering a new strategy to reveal lung squamous cell carcinoma progress.