Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fever and acute phase reactants in the rat.

H van Vugt1, J van Gool, N E Deutz

  • 1Department of Experimental Internal Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.

British Journal of Experimental Pathology
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictor Biomarkers of Nonelective Hospital Readmission and Mortality in Malnourished Hospitalized Older Adults.

The Journal of frailty & aging·2020
Same author

Request for regulatory guidance for cancer cachexia intervention trials.

Journal of cachexia, sarcopenia and muscle·2015
Same author

Metabolic changes of cancer cachexia--second of two parts.

Clinical nutrition (Edinburgh, Scotland)·2006
Same author

Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region.

Immunogenetics·2002
Same author

Results of a questionnaire evaluating different aspects of personal and familial situation, and the methods of potty-training in two groups of children with a different outcome of bladder control.

Scandinavian journal of urology and nephrology·2002
Same author

Intestinal function and metabolism in the early adaptive phase after massive small bowel resection in the rat.

Journal of pediatric surgery·2001

Fever in rats, induced by PGE2, triggers an acute phase response (APR). This response, involving corticosteroids and adrenaline, is crucial for synthesizing alpha-macrofetoprotein (alpha M FP).

Area of Science:

  • Physiology
  • Immunology
  • Neuroendocrinology

Background:

  • Corticosteroids and adrenaline can induce acute phase reactants (APRs) in rats.
  • Elevated plasma levels of these hormones are observed during fever.

Purpose of the Study:

  • To investigate the effect of fever, induced by intra-cerebroventricular (i.c.v.) injection of PGE2, on the acute phase response in rats.
  • To elucidate the hormonal and neural pathways involved in fever-induced APRs.

Main Methods:

  • Fever was induced in rats via i.c.v. injection of PGE2 or heat exposure.
  • Acute phase reactant response was measured by quantifying alpha-macrofetoprotein (alpha M FP) levels 24 hours post-induction.
  • Hormonal manipulations included adrenalectomy and alpha- or beta-adrenergic blockade.

Related Experiment Videos

  • Sympathetic nerve supply to the liver was disrupted using 6-OH dopamine.
  • Sodium salicylate was used to modulate hyperthermia.

    • Main Results:

    • PGE2-induced fever significantly increased alpha M FP levels, correlating with the maximal rise in body temperature.
    • Adrenalectomy completely abolished the APR, while fever magnitude remained unchanged.
    • Alpha-blockade reduced fever but did not affect APR.
    • Combined alpha- and beta-blockade abolished the APR despite a normal fever response.
    • Disruption of sympathetic innervation to the liver did not impede APR.
    • Induced hyperthermia via heat exposure elicited a comparable APR, suggesting fever itself, not just PGE2, triggers the response.
    • Sodium salicylate pretreatment resulted in variable alpha M FP increases during hyperthermia.

    Conclusions:

    • Fever, independent of tissue injury, effectively induces an acute phase response in rats.
    • The pathway likely involves circulating corticosterone and adrenaline, potentially mediated by beta-adrenergic stimulation.
    • Adrenal hormones play a critical role in mediating fever-induced APRs.