Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanical transduction in biological systems.

F Sachs1

  • 1Department of Biophysics, SUNY, Buffalo.

Critical Reviews in Biomedical Engineering
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Kinetics and the Permeation Properties of Piezo Channels.

Current topics in membranes·2017
Same author

Free Volume in Membranes: Viscosity or Tension?

Open journal of biophysics·2016
Same author

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Progress in biophysics and molecular biology·2011
Same author

Cardiac mechanosensitivity and stretch-activated ion channels.

Trends in cardiovascular medicine·2011
Same author

Membrane Electromechanics in Biology, with a Focus on Hearing.

MRS bulletin·2010
Same author

Thermodynamics of mechanosensitivity.

Physical biology·2005
Same journal

The Safety and Efficacy of Cardiac Stem Cell Therapy for Cardiovascular Disease: A Meta-Analysis of Randomized Controlled Trials.

Critical reviews in biomedical engineering·2026
Same journal

Local-Global-Graph Network-Based Biokey Generation with Electrocardiogram Signal and Lightweight Authentication in Cloud-Based Internet of Medical Things Networks.

Critical reviews in biomedical engineering·2026
Same journal

Diffusion Tensor Imaging for Brain Injury Assessment: Methodological Foundations and Clinical Insights.

Critical reviews in biomedical engineering·2026
Same journal

Novel Investigation of Hepatitis B Transmission Dynamics via Fractal-Fractional Operators of Variable and Constant Order with Memory Effects.

Critical reviews in biomedical engineering·2026
Same journal

An Improved YOLOv8-Based Object Detection Algorithm for Skin Diseases.

Critical reviews in biomedical engineering·2026
Same journal

A Numerical Comparison of Magnetic Nanoparticle Hyperthermia in Breast, Muscle, and Prostate Tumors.

Critical reviews in biomedical engineering·2025
See all related articles

Mechanical transduction converts cell deformation into electrical signals, vital for organism survival. This process, mediated by strain-gated ion channels, underlies senses like hearing and touch.

Area of Science:

  • Cellular Biology
  • Biophysics
  • Neuroscience

Background:

  • Mechanical transduction is fundamental for cellular and organismal survival.
  • Mechanotransducers are crucial for sensory functions including hearing, touch, and proprioception.
  • Cellular mechanoreception plays roles in basic life processes and environmental responses.

Purpose of the Study:

  • To elucidate the fundamental mechanisms of mechanical transduction in biological systems.
  • To explore the role of mechanotransducers in sensory perception and cellular regulation.
  • To investigate the molecular basis of mechanotransduction.

Main Methods:

  • Review and synthesis of existing literature on mechanotransduction.
  • Analysis of the properties of mechanosensitive ion channels.

Related Experiment Videos

  • Theoretical modeling of membrane strain-gated ion channel function.

    • Main Results:

    • Mechanical transduction is essential for survival across diverse organisms, from protozoans to plants and complex animals.
    • Specialized sensory organs and visceral systems rely on mechanoreception for feedback.
    • The properties of known mechanotransducers are explained by ion channels gated by membrane strain.

    Conclusions:

    • Mechanotransduction, the conversion of mechanical stimuli to electrochemical signals, is a ubiquitous biological process.
    • Strain-gated ion channels are the likely molecular entities responsible for mechanical transduction.
    • Understanding mechanotransduction is key to comprehending sensory biology and cellular homeostasis.