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Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study
Jonatan R Ruiz1, Idoia Labayen2, Francisco B Ortega1
11] PROFITH "PROmoting FITness and Health through physical activity" Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain [2] Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden.
Background:
To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries.
Methods:
The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and the AST/ALT ratio was computed.
Results:
There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels.
Conclusion:
Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.
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