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Updated: May 2, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic esophagitis and allergy.

Dagmar Simon¹, Alex Straumann, Hans-Uwe Simon

¹Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.

Digestive Diseases (Basel, Switzerland)

|March 8, 2014

Summary

Adults with eosinophilic esophagitis (EoE) often show sensitization to airborne and food allergens, but symptoms don't always link to specific food allergies. Identifying triggers requires elimination diets and further research is needed.

Area of Science:

Immunology
Gastroenterology
Allergology

Background:

Eosinophilic esophagitis (EoE) is frequently linked to other allergic conditions like asthma and eczema.
Understanding allergen sensitization patterns in adult EoE is crucial for diagnosis and treatment.

Purpose of the Study:

To review the current literature on allergen sensitization in adult EoE patients.
To critically evaluate diagnostic and therapeutic tools for EoE.

Main Methods:

Literature review of studies on adult EoE patients.
Analysis of sensitization patterns using specific IgE levels and skin prick tests.
Discussion of diagnostic methods like elimination diets and histological analysis.

Main Results:

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Most adult EoE patients have elevated total IgE and sensitization to aero- and food allergens.
Unlike children, adult EoE symptoms do not consistently correlate with IgE sensitization to specific foods.
Sensitization to cross-reactive plant components (profilins, PR10 proteins) is found in two-thirds of adult EoE patients.

Conclusions:

While sensitization to allergens is common in adult EoE, specific food triggers are difficult to pinpoint via IgE testing alone.
Elimination diets followed by endoscopic reintroduction are currently the primary method for identifying food triggers.
Further research is essential to clarify the role of allergens in EoE pathogenesis and to develop targeted diagnostic and treatment strategies.