Related Experiment Video
Updated: May 2, 2026

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
Using the Immunization Information System to determine vaccination coverage rates among children aged 1-7 years: a
Qian Li1, Yu Hu2, Yanpeng Zhong3
1Institute of Immunization and Prevention, Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China. qianli@cdc.zj.cn.
Insights
The Zhejiang Immunization Information System (ZJIIS) shows improving National Immunization Program (NIP) vaccine coverage in children aged 1-7 years. However, coverage for vaccines given after 12 months and for migrant children needs improvement.
Area of Science:
- Public Health
- Epidemiology
- Vaccinology
Background:
- The Zhejiang Immunization Information System (ZJIIS) was established in 2004 to monitor vaccine administration.
- This study analyzes National Immunization Program (NIP) vaccine coverage in Zhejiang Province using ZJIIS data.
Purpose of the Study:
- To describe NIP vaccine coverage rates in children aged 1-7 years in Zhejiang Province.
- To identify trends, patterns, and disparities in vaccine administration using cohort data.
Main Methods:
- A cohort of 3,579,896 children (born 2005-2011) registered in ZJIIS was analyzed.
- Immunization records were obtained as of December 31, 2012.
- Coverage was assessed by vaccine, age group, birth cohort, immigration status, and geography, including timeliness for the 2010 birth cohort.
Main Results:
- Vaccine coverage for doses scheduled at ≤12 months exceeded 90%.
- Coverage decreased significantly for vaccines scheduled after 12 months, falling below 90%.
- Migrant children and those in WenZhou, Zhoushan, and TaiZhou municipalities showed lower coverage. Delays in primary series vaccination were noted, particularly among migrant children in the 2010 birth cohort.
Conclusions:
- ZJIIS is effective for tracking vaccine coverage and demonstrates improving NIP delivery in Zhejiang.
- Identified disparities highlight areas needing targeted interventions to enhance vaccine uptake.
- Continued surveillance via ZJIIS and implementation of strategies like reminder/recall and school-based programs are recommended.
Background:
The Zhejiang Immunization Information System (ZJIIS) was established in 2004. This study described the coverage rates of NIP vaccines in Zhejiang Province using the ZJIIS.
Methods:
Children aged 1-7 years (born from 1 January 2005 to 31 December 2011) registered in ZJIIS were enrolled in this study. All immunization records were obtained from the ZJIIS on 31 December 2012. The cohort method had been used for identifying trends and patterns in vaccine administration. Immunization coverage estimates were analyzed for both individual NIP vaccines and "Fully immunized" by age group, birth cohort, immigration status, and geography area. We also examined the timeliness vaccination for the 2010 birth cohort.
Results:
A total of 3,579,896 children were registered in ZJIIS. All the vaccines and doses which scheduled to be given at ≤ 12 months of age exceeded 90%. There was substantial decrease trend in the vaccines scheduled at >12 months of age and most of these vaccines were below 90%. The coverage of migrant children was lower than for resident children and the coverage of WenZhou (WZ), Zhoushan (ZS) and TaiZhou (TZ) was lower than other municipalities for most of vaccines across all the birth cohorts. Nearly 20%-30% of children of 2010 birth cohort delayed for the primary series vaccination scheduled at ≤ 12 months of age, especially among migrant children.
Conclusions:
The ZJIIS is useful in tracking vaccine coverage of children aged 1-7 years and the data provided by ZJIIS reflected the fact that NIP delivery was improving in Zhejiang Province, while identifying some areas for improvement. We recommend continuing surveillance to estimate of vaccine coverage through ZJIIS. Immunization strategies such as Assessment, Feedback, Incentives, and Exchange program, reminder/recall activity, home visits, school entry requirements and school-based clinics could be used to reach a higher coverage of the population.
More Related Videos
06:22Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
Published on: February 10, 2023
05:39Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
Published on: October 30, 2018
Related Concept Videos
Vaccinations
Principles of Disease Surveillance
Statistical Methods for Analyzing Epidemiological Data
Investigation of Disease Outbreaks