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Updated: May 2, 2026
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Published on: May 30, 2025
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Long non-coding RNAs in colorectal cancer: implications for pathogenesis and clinical application
Summary
Long non-coding RNAs (lncRNAs) are key regulators in colorectal cancer (CRC) development. Understanding their dysregulation offers potential for improved CRC diagnostics, prognostics, and targeted therapies.
Area of Science:
- Molecular Biology
- Oncology
Background:
- Colorectal cancer (CRC) is a significant global health issue.
- Current CRC screening, diagnostic, and therapeutic strategies require refinement.
- Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial in cancer development.
Purpose of the Study:
- To review the functions of lncRNAs associated with CRC.
- To explore molecular mechanisms behind aberrant lncRNA expression in CRC.
- To assess the clinical and therapeutic potential of CRC-associated lncRNAs.
Main Methods:
- Literature review of CRC-associated lncRNAs.
- Analysis of molecular mechanisms in lncRNA dysregulation.
- Evaluation of diagnostic, prognostic, and therapeutic implications.
Main Results:
- Dysregulated lncRNAs are implicated in CRC initiation and progression.
- Various regulatory factors contribute to aberrant lncRNA expression in CRC.
- lncRNA expression patterns correlate with CRC stages and patient outcomes.
Conclusions:
- lncRNAs play significant roles in colorectal cancer tumorigenesis.
- Aberrant lncRNA expression is linked to CRC development and progression.
- CRC-associated lncRNAs show promise as diagnostic, prognostic, and therapeutic targets.
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