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Cleavage of specific sites of RNA by designed ribozymes
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
FEBS Letters
|November 7, 1988
Abstract:
Two ribozymes were designed for site-specific cleavage of RNA. A UA site in an undecaribonucleotide was cleaved by a ribozyme consisting of two partially paired oligoribonucleotides with chain lengths of 19 and 15. The other ribozyme, which consists of a 19-mer and a 13-mer, recognized a UC sequence at positions 42 and 43 of 5 S rRNA.