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Updated: May 2, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
[Colorectal cancer (CCR): genetic and molecular alterations]
Clara Ibet Juárez-Vázquez1, Mónica Alejandra Rosales-Reynoso
1Universidad de Guadalajara, Guadalajara, Jal. mareynoso77@yahoo.com.mx.
Abstract:
The aim of this review is to present a genetic and molecular overview of colorectal carcinogenesis (sporadic and hereditary origin) as a multistage process, where there are a number of molecular mechanisms associated with the development of colorectal cancer and genomic instability that allows the accumulation of mutations in proto-oncogenes and tumor suppressor genes, chromosomal instability, and methylation and microsatellite instability, and the involvement of altered expression of microRNAs' prognosis factors.
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