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Liver transplantation for malignancies
Bijan Eghtesad1, Federico Aucejo
1Hepato-pancreato-biliary/Liver Transplant Surgery, Cleveland Clinic, Desk A-100, 9500 Euclid Avenue, Cleveland, OH, 44195, USA, eghtesb@ccf.org.
Journal of Gastrointestinal Cancer
|March 8, 2014
Summary
Liver transplantation (LT) offers excellent outcomes for select liver cancers like hepatocellular carcinoma and hepatic epithelioid hemangioendothelioma. However, outcomes vary significantly for other malignancies, with disappointing results for angiosarcoma.
Area of Science:
- Hepatobiliary Malignancies
- Transplant Oncology
- Surgical Oncology
Background:
- Liver transplantation (LT) is an established treatment for hepatocellular carcinoma.
- Its application is expanding to other primary and secondary liver malignancies.
- Outcomes vary widely depending on the specific cancer type.
Purpose of the Study:
- To review the outcomes of liver transplantation for various primary and secondary liver cancers.
- To evaluate the efficacy of LT in different oncological indications.
- To identify factors influencing post-transplant survival in liver cancer patients.
Main Methods:
- Review of existing literature and outcomes data for LT in liver malignancies.
- Analysis of survival rates and recurrence patterns for different cancer types.
- Comparison of LT effectiveness across various oncological indications.
Main Results:
- Excellent outcomes reported for hepatocellular carcinoma, hilar cholangiocarcinoma, hepatic epithelioid hemangioendothelioma, and pediatric hepatoblastoma.
- Disappointing results and no long-term survivors for angiosarcoma.
- Promising outcomes for neuroendocrine tumors with low activity, despite recurrence.
- Limited survival benefit and high recurrence rates for colorectal cancer metastases.
Conclusions:
- LT is a viable option for specific liver malignancies with favorable outcomes.
- Tumor type is a critical determinant of LT success.
- Careful patient selection is crucial, especially for indications with high recurrence rates like colorectal cancer metastases.
