Negishi coupling: an easy progress for C-C bond construction in total synthesis

Area of Science:

• Organic Chemistry
• Synthetic Chemistry
• Natural Product Synthesis

Background:

• Negishi cross-coupling is a cornerstone reaction in organic synthesis.
• Its application is widespread in the total synthesis of complex natural products.
• Recent advancements have expanded its utility and efficiency.

Purpose of the Study:

• To review the strategic role of Negishi cross-coupling in recent natural product total synthesis.
• To highlight the advancements in Negishi coupling methodologies.
• To underscore the importance of this reaction in constructing carbon-carbon bonds.

Main Methods:

• Review of literature focusing on Negishi cross-coupling in total synthesis.
• Analysis of substrate scope, reaction conditions, and selectivity.
• Examination of sequential processes and green chemistry aspects.

Main Results:

• Negishi coupling facilitates efficient carbon-carbon bond formation.
• Expanded substrate scope and improved stereoselectivity are key advancements.
• Development of mild, non-toxic reaction conditions enhances its applicability.

Conclusions:

• Negishi cross-coupling remains a powerful and versatile method for natural product synthesis.
• Continued development ensures its strategic importance in constructing complex molecules.
• The reaction's maturity and green attributes solidify its role in modern synthetic chemistry.