Negishi coupling: an easy progress for C-C bond construction in total synthesis
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Majid M Heravi1, Elaheh Hashemi, Niousha Nazari
1Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran, mmh1331@yahoo.com.
Abstract:
Negishi cross-coupling reactions were used extensively in total synthesis. The expansion of substrate scope, the development of mild reaction conditions, the advancement of the methods to improve the stereo- and regio-selectivity of carbon-carbon bond formation, the maturity of a large number of sequential processes, and the development of non-toxic reactions signify the importance of Negishi coupling. The following review illustrates a strategic role of this reaction in constructing carbon-carbon bonds in the recent total synthesis of natural products.
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