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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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Related Experiment Video

Updated: May 2, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

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Published on: March 9, 2015

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Anidulafungin-induced alopecia.

J Ruiz-Ramos1, M Salavert-Lleti, E Monte-Boquet

  • 1Hospital Universitari i Politècnic La Fe, Valencia, Spain.

The Annals of Pharmacotherapy
|March 8, 2014
PubMed
Summary

Anidulafungin, an antifungal medication, may cause hair loss in patients. This case report suggests a probable link between anidulafungin use and alopecia, prompting awareness among healthcare providers.

Keywords:
adverse drug reactionsalopeciaanidulafunginhair loss

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Area of Science:

  • Mycology
  • Dermatology
  • Pharmacology

Background:

  • Chronic osteomyelitis and Candida albicans infections require effective antifungal therapy.
  • Anidulafungin is an echinocandin antifungal agent used in treating invasive fungal infections.
  • Alopecia is a known side effect of some antifungal medications, particularly azoles.

Observation:

  • A 34-year-old woman developed alopecia after several months of anidulafungin treatment for Candida albicans osteomyelitis.
  • Hair loss was noted to increase with anidulafungin use and resolved upon discontinuation.
  • Hair loss reappeared upon re-initiation of anidulafungin, suggesting a probable causal relationship.

Findings:

  • The Naranjo scale indicated a probable association between anidulafungin and drug-induced hair loss.
  • This is the first reported case linking anidulafungin (an echinocandin) to alopecia.
  • The adverse effect appears to be reversible upon drug withdrawal and potentially manageable upon re-challenge.

Implications:

  • Anidulafungin may be associated with hair loss, an adverse effect not previously documented for echinocandins.
  • Clinicians should monitor patients for alopecia during anidulafungin therapy.
  • Awareness of this potential side effect can help manage patient adherence and treatment outcomes.