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Updated: May 2, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone
Chuqin Peng1, Jiwei Ren1, Jun-An Xiao1
1School of Chemistry and Chemical Engineering, Central South University,Changsha, Hunan 410083, P. R. China.
Abstract:
1,3-Dipolar cycloadditions of isatins, benzylamine and benzylideneacetones were studied to prepare a series of novel spiropyrrolidine-oxindoles - 4'-acetyl-3',5'-diarylspiro[indoline-3,2'-pyrrolidin]-2-ones and 3'-acetyl-4',5'-diarylspiro[indoline-3,2'-pyrrolidine]-2-ones in good yields of up to 94% and with good regioselectivities. Regioselectivities are reversible by the addition of water or 4-nitrobenzoic acid, respectively. The substituent effects on the regioselectivity were also investigated.
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