Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.1K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

8.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.4K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.1K
What is the Skeletal System?01:02

What is the Skeletal System?

45.7K
Overview
45.7K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Prime Editing Efficiency in Human Immortalized MSC-TERT Cells with Osteogenic Potential for Modeling <i>FGFR2</i>-Linked Craniosynostosis.

The CRISPR journal·2026
Same author

Generation of human induced pluripotent stem cell lines from patients with FGFR2-linked syndromic craniosynostosis.

Disease models & mechanisms·2025
Same author

Connecting the dots: (RANKL<sup>+</sup>) extracellular vesicle count in blood plasma in relation to bone metastases, skeletal related events and osimertinib treatment in patients with EGFR mutated non-small cell lung cancer.

Translational lung cancer research·2025
Same author

Dynamic strain and β-catenin mediated suppression of interferon responsive genes in quiescent mesenchymal stromal/stem cells.

Biochemistry and biophysics reports·2024
Same author

Organic phosphate but not inorganic phosphate regulates <i>Fgf23</i> expression through MAPK and TGF-ꞵ signaling.

iScience·2024
Same author

Epigenetic regulators controlling osteogenic lineage commitment and bone formation.

Bone·2024

Related Experiment Video

Updated: May 2, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

8.8K

Vitamin D endocrine system and osteoblasts.

Marjolein van Driel1, Johannes P T M van Leeuwen1

  • 1Department of Internal Medicine, Erasmus MC , Rotterdam, The Netherlands.

Bonekey Reports
|March 8, 2014
PubMed
Summary

Vitamin D directly impacts bone cells, influencing their growth and function. However, these vitamin D effects on osteoblasts vary significantly based on factors like cell type and treatment specifics.

Area of Science:

  • Endocrinology
  • Cell Biology
  • Bone Metabolism

Background:

  • The vitamin D endocrine system plays a crucial role in bone health.
  • Osteoblasts are key cells responsible for bone formation and mineralization.
  • The interaction between vitamin D and osteoblasts is intricate and multifaceted.

Purpose of the Study:

  • To provide an overview of the current understanding of the vitamin D endocrine system in osteoblasts.
  • To explore the direct effects of 1α,25-dihydroxyvitamin D3 (1α,25D3) on osteoblast function.
  • To analyze factors influencing vitamin D's impact on osteoblast proliferation, differentiation, and mineralization.

Main Methods:

  • Review of existing scientific literature on vitamin D and osteoblasts.
  • Analysis of in vitro studies investigating osteoblast responses to 1α,25D3.

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

23.6K
IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.8K

Related Experiment Videos

Last Updated: May 2, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

8.8K
Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

23.6K
IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.8K
  • Examination of gene expression and molecular mechanisms involved in vitamin D signaling in osteoblasts.

    • Main Results:

    • Osteoblasts possess the vitamin D receptor (VDR), enabling direct action by 1α,25D3.
    • Vitamin D influences osteoblast proliferation, differentiation, and mineralization, with effects varying by cell origin (human/rat vs. murine) and experimental conditions.
    • Osteoblasts express a membrane-bound receptor for vitamin D and can synthesize 1α,25D3.

    Conclusions:

    • The effects of vitamin D on osteoblasts are complex and modulated by numerous factors.
    • Understanding these interactions is vital for comprehending bone formation and potential therapeutic strategies.
    • Further research into the classical VDR, membrane receptors, and local synthesis is warranted.