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Decrease of sperm antibody titer in males, and conception after treatment of chronic prostatitis.

B Fjällbrant, S Nilsson

    International Journal of Fertility
    |January 1, 1977
    PubMed
    Summary
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    Treating prostatitis may reduce sperm antibodies in infertile men, potentially improving sperm function and leading to conception. This offers a new avenue for male infertility treatment by addressing underlying infections.

    Area of Science:

    • Reproductive immunology
    • Urology
    • Male infertility

    Background:

    • Autoimmunization to spermatozoa is a known cause of male infertility.
    • The etiology of sperm antibody formation remains largely unknown.
    • Previous attempts to reduce sperm antibody titers have been unsuccessful.
    • A higher incidence of prostatitis was observed in men with sperm antibodies compared to controls.

    Purpose of the Study:

    • To investigate the potential of treating prostatitis as a therapeutic approach for male infertility associated with sperm antibodies.
    • To evaluate the effect of prostatitis treatment on sperm antibody titers and sperm function.

    Main Methods:

    • A cohort of men with sperm antibodies and prostatitis was identified.
    • Prostatitis was treated using standard therapeutic methods.

    Related Experiment Videos

  • Sperm antibody titers were monitored before and after treatment.
  • Cervical mucus penetrating capacity of spermatozoa was assessed.
  • Conception rates were recorded.

    • Main Results:

    • Treatment of prostatitis led to a reduction in sperm antibody titers in eight cases.
    • In five cases, the cervical mucus penetrating capacity of spermatozoa improved post-treatment.
    • Conception occurred in five cases following the intervention.

    Conclusions:

    • Prostatitis may play a role in the development or maintenance of sperm autoimmunity.
    • Treatment of prostatitis presents a potential therapeutic strategy for reducing sperm antibodies and improving fertility in affected men.
    • Further research is warranted to confirm these findings and elucidate the underlying mechanisms.