Related Experiment Video

Updated: May 2, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
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A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

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Runx1-mediated regulation of osteoclast differentiation and function

Do Y Soung1, Judith Kalinowski, Sanjeev K Baniwal

  • 1New England Musculoskeletal Institute (D.Y.S., J.K., C.E.J.-G., J.L., H.D.), Department of Orthopaedic Surgery (H.D.), and Department of Medicine (C.E.J.-G.), University of Connecticut Health Center, Farmington, Connecticut 06030; and Department of Orthopaedic Surgery and Biochemistry and Molecular Biology (S.K.B., B.F.), University of Southern California, Los Angeles, California 90089.

Molecular Endocrinology (Baltimore, Md.)
|March 11, 2014
PubMed
Summary

Runx1, a key regulator in blood cell development, was found to inhibit osteoclast formation and activity. Its absence in preosteoclasts leads to reduced bone mass and increased bone resorption, highlighting its role in skeletal health.

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