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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Related Experiment Video

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Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
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Perinatal heart programming: long-term consequences.

A Faa, R Ambu, G Faa

  • 1Department of Surgical Sciences, Section of Pathology, University of Cagliari, Cagliari, Italy. armando.faa@hotmail.it.

Current Medicinal Chemistry
|March 11, 2014
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Summary
This summary is machine-generated.

Impaired intrauterine growth programs adult cardiovascular disease risk. Early intervention in childhood may improve long-term outcomes, highlighting the need for prenatal prevention strategies.

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Area of Science:

  • Developmental biology
  • Cardiovascular medicine
  • Epigenetics

Background:

  • Intrauterine growth restriction (IUGR) is linked to adult cardiovascular disease.
  • The number of cardiomyocytes at birth may influence future heart health.
  • Epigenetic programming during fetal development has long-term health implications.

Purpose of the Study:

  • To evaluate the relationship between impaired intrauterine growth and adult cardiovascular disease risk.
  • To explore the impact of fetal development on lifelong heart health.
  • To discuss the potential for early intervention in pediatric cardiovascular disease.

Main Methods:

  • Literature review focusing on intrauterine fetal development and heart disease.
  • Schematic representation of human heart development.
  • Discussion of theories on cardiomyocyte number at birth.

Main Results:

  • The intrauterine environment shapes newborn epigenetic profiles, influencing adult disease risk.
  • Cardiovascular risk and obesity programming begins during fetal life.
  • Prenatal factors significantly impact long-term cardiovascular health.

Conclusions:

  • Preventing and treating pediatric cardiovascular diseases may alter adult complication management.
  • Discovering molecular mechanisms linking IUGR to adult cardiac disease is a future challenge.
  • Primary prevention of adult heart disease in utero is a potential future goal.