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Early decrease of insulin sensitivity in offspring of individuals with type 2 diabetes. The Mexican Diabetes
Ricardo Pérez-Fuentes1, Blanca G Baez-Duarte2, Irma Zamora-Ginez2
1Laboratorio de Investigación en Fisiopatología de Enfermedades Crónicas, Centro de Investigación Biomédica de Oriente (CIBIOR), Instituto Mexicano del Seguro Social (IMSS), Atlixco, Puebla, Mexico; Facultad de Medicina, Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Mexico.
Archives of Medical Research
|March 11, 2014
Summary
Offspring of type 2 diabetes (T2D) patients show decreased insulin sensitivity (IS) with age. This decline in IS is an early sign of metabolic dysfunction in middle-aged adults, independent of obesity.
Area of Science:
- Endocrinology
- Metabolic Health
- Diabetes Research
Background:
- Insulin sensitivity (IS) and secretion defects are risk factors for type 2 diabetes (T2D).
- Understanding these defects in at-risk populations is crucial for early detection and prevention.
Purpose of the Study:
- To investigate the relationship between healthy offspring of individuals with T2D (OFD+) and insulin sensitivity.
- To identify early metabolic abnormalities in a Mexican population.
Main Methods:
- A cohort of 602 Mexican adults (18-65 years) was studied, including 359 OFD+ and 243 controls (OFD-).
- Insulin sensitivity was assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI).
- Homeostasis model assessment B (HOMA-B) was used to evaluate B cell function.
Main Results:
- Middle-aged OFD+ individuals exhibited significantly lower IS (QUICKI) compared to OFD- individuals.
- The prevalence of decreased IS and increased fasting insulin levels was highest in middle-aged OFD+.
- OFD+ status was independently associated with increased fasting insulin levels and decreased IS.
Conclusions:
- Decreased insulin sensitivity may be an early detectable abnormality in middle-aged adults.
- The prevalence of reduced IS increases with age and is linked to having a parent with T2D, irrespective of obesity.
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