Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

14.8K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Living Together, Loving Apart: Health, Sexuality and Relationships in Middle-Aged and Older Men in Europe.

Andrology·2026
Same author

Maternal dopamine agonist treatment before pregnancy reverses infertility and hyperprolactinemia in hCG-overexpressing mice through lactation: Evidence of generational effects.

Molecular and cellular endocrinology·2025
Same author

Comment on "Atlas of Fshr Expression From Novel Reporter Mice".

Endocrinology·2025
Same author

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology·2025
Same author

Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue.

Molecular medicine (Cambridge, Mass.)·2024
Same author

The Loss of Estradiol by Androgen Deprivation in Prostate Cancer Patients Shows the Importance of Estrogens in Males.

Journal of the Endocrine Society·2024
Same journal

In ovo silencing of SERPINA6 using siRNA alters endocrine responses and embryonic growth in broiler chickens.

Reproductive biology·2026
Same journal

The effects of flavonoids on female animal reproductive performance.

Reproductive biology·2026
Same journal

Current status and future directions of in vitro embryo production in wild and non-traditional livestock mammals from South America.

Reproductive biology·2026
Same journal

Novel RHOXF1 mutation causes male infertility by inducing severe oligoasthenozoospermia.

Reproductive biology·2026
Same journal

Paternal finasteride exposure and its impact on offspring testicular histopathology and intracellular junctions: the role of occludin and N-cadherin.

Reproductive biology·2026
Same journal

JAK/STAT signaling pathway in the spleen and liver during early pregnancy in ewes.

Reproductive biology·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

8.2K

Genetically modified mouse models addressing gonadotropin function.

Laura D Ratner1, Susana B Rulli1, Ilpo T Huhtaniemi2

  • 1Instituto de Biología y Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina.

Reproductive Biology
|March 11, 2014
PubMed
Summary
This summary is machine-generated.

Transgenic mice with chronic human chorionic gonadotropin (hCG) hypersecretion develop reproductive abnormalities. Hyperprolactinemia, driven by progesterone, causes infertility and tumors, but dopamine agonists can normalize these conditions.

Keywords:
Human chorionic gonadotropinHyperprolactinemiaPituitaryProlactinomaTransgenic mice

More Related Videos

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.1K
Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation
08:06

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation

Published on: May 5, 2023

4.4K

Related Experiment Videos

Last Updated: May 2, 2026

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

8.2K
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.1K
Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation
08:06

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation

Published on: May 5, 2023

4.4K

Area of Science:

  • Reproductive endocrinology
  • Molecular endocrinology
  • Transgenic animal models

Background:

  • Gonadotropin regulation is crucial for reproductive function.
  • Human chorionic gonadotropin (hCG) is structurally and functionally related to luteinizing hormone (LH).
  • Elevated LH/hCG levels can cause reproductive abnormalities.

Purpose of the Study:

  • To investigate the impact of chronic hCG hypersecretion on the hypothalamic-pituitary-gonadal axis.
  • To elucidate mechanisms of pituitary tumorigenesis and hyperprolactinemia in a transgenic mouse model.
  • To explore the role of progesterone and dopamine agonists in this model.

Main Methods:

  • Development of a transgenic mouse model with chronic hCG hypersecretion.
  • Phenotypic analysis of gonadal and extragonadal abnormalities.
  • Investigation of hormonal relationships, including progesterone and prolactin.
  • Assessment of dopamine agonist (bromocriptine, cabergoline) efficacy.

Main Results:

  • Female mice exhibited obesity, infertility, hyperprolactinemia, and pituitary/mammary tumors.
  • Progesterone was linked to the hyperprolactinemic condition.
  • Hyperprolactinemia was identified as the primary cause of infertility and phenotypic abnormalities.
  • Dopamine agonists normalized hyperprolactinemia and associated conditions.

Conclusions:

  • Chronic hCG hypersecretion in mice leads to significant reproductive and endocrine disruptions.
  • Hyperprolactinemia, influenced by progesterone, is a key mediator of these abnormalities.
  • Dopamine agonists represent a potential therapeutic strategy for hCG-induced reproductive dysfunction.