Related Experiment Video
Updated: Feb 28, 2026
Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
Published on: June 11, 2019
Heps with pep: direct reprogramming into human hepatocytes
1Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Institute for Regenerative Medicine, Department of Surgery, West Forvie Site, Robinson Way, Cambridge CB20SZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Abstract:
The limited supply and expansion capacity of primary human hepatocytes presents major challenges for pharmaceutical applications and development of cell-based therapies for liver diseases. Now in Cell Stem Cell, two papers demonstrate efficient direct reprogramming of human fibroblasts into induced hepatocytes, which exhibit metabolic properties similar to primary hepatocytes.
