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Updated: May 2, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Vascular endothelial growth factor gene polymorphisms and vasculitis susceptibility: A meta-analysis
Gwan Gyu Song1, Jae-Hoon Kim1, Young Ho Lee1
1Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Objective:
The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms are associated with susceptibility to vasculitis.
Methods:
Meta-analyses were conducted on the associations between the -634 C/G, +936 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and vasculitis.
Results:
Eight studies on VEGF polymorphisms and vasculitis involving 2740 subjects (vasculitis 834, controls 1906) were included in this meta-analysis. The meta-analysis showed no association between vasculitis and the VEGF -634 C allele (OR=1.161, 95% CI=0.921-1.464, p=0.207) among study subjects. Meta-analysis showed no association between vasculitis and the VEGF+936 T allele (OR=1.121, 95% CI=0.905-1.390, p=0.295). However, stratification by ethnicity indicated a significant association between the VEGF+936 T allele and vasculitis in Europeans, but not in Asians (OR=1.486, 95% CI=1.038-2.128, p=0.030; OR=0.958, 95% CI=0.773-1.253, p=0.755). Meta-analysis showed no association between vasculitis and the VEGF -1154 A/G and 2578 A/C polymorphisms.
Conclusions:
This meta-analysis suggests that the VEGF+936 T allele is associated with susceptibility to vasculitis in Europeans, but not in Asians.
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