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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Circulating small noncoding RNAs as biomarkers of aging
1Department of Biochemistry, University of California at Riverside, Riverside, CA 92521, USA; Center for Genetics, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Ageing Research Reviews
|March 11, 2014
Summary
Circulating small noncoding RNAs (sncRNAs) in blood, including microRNAs (miRNAs), may signal between cells and influence aging. Calorie restriction impacts their levels, suggesting physiological control.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Small noncoding RNAs (sncRNAs) are crucial for cellular functions in various organisms.
- Deep sequencing reveals circulating sncRNAs in mammalian blood, including microRNAs (miRNAs), 5' tRNA halves, and YRNA fragments.
Purpose of the Study:
- To investigate the role and characteristics of circulating sncRNAs.
- To explore the potential of sncRNAs as signaling molecules and their involvement in aging processes.
Main Methods:
- Deep sequencing of biological specimens to identify and quantify sncRNAs.
- Analysis of sncRNA characteristics, abundance, and cellular uptake mechanisms.
Main Results:
- Circulating sncRNAs, particularly miRNAs, can enter cells and regulate cellular functions.
- Serum levels of specific sncRNAs change with age and are influenced by calorie restriction (CR).
Conclusions:
- Circulating sncRNAs possess properties consistent with intercellular signaling molecules.
- Changes in sncRNA levels with age suggest their implication in aging mechanisms, warranting further investigation.
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