Related Experiment Video

Updated: May 2, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

16.8K

Nonreentrant ventricular arrhythmias in patients with structural heart disease unrelated to abnormal myocardial

Ethan R Ellis1, Alexei Shvilkin1, Mark E Josephson1

  • 1Harvard-Thorndike Electrophysiology Institute, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Heart Rhythm
|March 11, 2014
PubMed

Insights

Nonreentrant ventricular arrhythmias are common in patients with structural heart disease. Their origins differ from those in patients with normal hearts, impacting treatment and outcomes.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Ventricular arrhythmias without structural heart disease are termed 'idiopathic.'
  • Prevalence of ventricular arrhythmias in structural heart disease is not well-defined.
  • Mechanisms and origins of ventricular arrhythmias are similar in both groups.

Purpose of the Study:

  • Determine the prevalence of nonreentrant ventricular arrhythmias in structural heart disease.
  • Compare these arrhythmias to those in structurally normal hearts.

Main Methods:

  • Analyzed 249 patients undergoing ventricular arrhythmia ablation.
  • Identified 97 patients (39%) with nonreentrant arrhythmias unrelated to structural heart disease.
  • Categorized patients into structurally normal hearts (55) and structural heart disease (42).

Main Results:

  • Patients with structural heart disease more often had nonreentrant ventricular arrhythmias originating from aortic cusps and left ventricular outflow tract.
  • Patients without structural heart disease more frequently had arrhythmias from the right ventricular outflow tract.
  • Left ventricular ejection fraction significantly improved post-ablation in structural heart disease patients.

Conclusions:

  • Nonreentrant ventricular arrhythmias are frequent in structural heart disease, with distinct origins.
  • Understanding arrhythmia mechanism, origin, and substrate is crucial for managing structural heart disease patients.
  • This knowledge may guide future treatment strategies and improve patient outcomes.
Abstract

Keywords:
CardiomyopathyCoronary artery diseaseIdiopathic ventricular tachycardiaLeft ventricular dysfunctionMyocardial infarctionOutflow tract tachycardiaPremature ventricular contractionsStructural heart diseaseTachycardia-mediated cardiomyopathy

More Related Videos

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

16.6K
A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts07:56

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

Published on: February 17, 2023

1.4K

Related Concept Videos

Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
5.3K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.7K
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
1.2K
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
735
Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
788
Dysrhythmias III: Characteristics of Dysrhythmias01:29

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
709