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Parasternal lymphoscintigraphy using 99Tcm-dextran.

B Karayalcin¹, G Aras, G Erbay

¹Department of Nuclear Medicine, Ankara University Medical School, Turkey.

Nuclear Medicine Communications

|September 1, 1988

Summary

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Technetium-99m-dextran is a promising radiopharmaceutical for lymphoscintigraphy, offering a simpler, cost-effective alternative to radiocolloids for visualizing lymph node drainage in breast cancer patients.

Area of Science:

Nuclear Medicine
Radiopharmacology

Background:

Lymphoscintigraphy is crucial for staging breast cancer.
Current agents like radiocolloids have limitations.

Purpose of the Study:

To evaluate 99mTc-dextran as a lymphoscintigraphic agent.
To compare its efficacy with radiocolloids.

Main Methods:

10 healthy volunteers and 24 breast cancer patients received 99mTc-dextran injections.
Lymphatic drainage patterns were visualized using scintigraphy at various time points.

Main Results:

99mTc-dextran successfully visualized lymph node distribution, including parasternal and supraclavicular nodes.
Abnormal patterns were identified in 8 out of 24 breast cancer patients.

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Results showed good agreement with literature using radiocolloids.

Conclusions:

99mTc-dextran is a viable and promising agent for lymphoscintigraphy.
Its ease of labeling, stability, availability, and low cost make it a potential replacement for radiocolloids.