Related Experiment Videos
Pediatric AIDS. Neuroradiologic and neurodevelopmental findings
D B Price1, C M Inglese, J Jacobs
1Department of Radiology, State University of New York Health Science Center, Brooklyn.
Insights
Over 95% of pediatric HIV patients showed neurodevelopmental delays. Computed tomography (CT) revealed common findings like enlarged cerebrospinal fluid (CSF) spaces, differing from adult HIV patients.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Neuroradiology
Background:
- Human Immunodeficiency Virus (HIV) infection can impact neurological development in children.
- Understanding the neuroimaging findings in pediatric HIV is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the neurodevelopmental outcomes and computed tomography (CT) findings in a cohort of HIV-seropositive pediatric patients.
Main Methods:
- A group of 23 HIV-seropositive pediatric patients underwent neurodevelopmental evaluation.
- Computed tomography (CT) scans were performed to assess brain structure and identify abnormalities.
Main Results:
- Significant neurodevelopmental delays were observed in over 95% of the studied pediatric patients.
- CT scans showed prominent cerebrospinal fluid (CSF) spaces in 57% of patients.
- Less common findings included basal ganglia and white matter calcifications, lymphoma, and cerebral hemorrhage.
Conclusions:
- Pediatric HIV infection is strongly associated with neurodevelopmental delays.
- CT findings in pediatric HIV differ from adults, with a lower incidence of contrast-enhancing inflammatory mass lesions.
Abstract:
A group of 23 pediatric patients seropositive for HIV antibody were studied by computed tomography and evaluated neurodevelopmentally. Significant neurodevelopmental delays were found in over 95% of the patients studied. CT findings in six patients were normal and thirteen of 23 (57%) had prominence of the CSF spaces. Less frequent findings included calcifications in the basal ganglia and white matter. Cerebral mass lesions included one case of lymphoma and one case of hemorrhage. The CT findings in the pediatric age group differs from the adult population in that contrast enhancing inflammatory mass lesions are uncommon.