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Pediatric orbital hemangiopericytoma associated with trisomy 15
Ashwinee P Ragam1, Neena Mirani, Gordana L Katava
1*Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School; and †Department of Pathology, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.
Insights
This study details an orbital hemangiopericytoma (HPC) in an infant, revealing trisomy 15. This rare chromosomal abnormality in HPC is documented in only two infant cases.
Area of Science:
- Oncology
- Genetics
- Ophthalmology
Background:
- Orbital hemangiopericytoma (HPC) is a rare vascular tumor.
- Infantile orbital tumors require precise diagnosis and management.
Observation:
- A case of orbital hemangiopericytoma was diagnosed in a 7-week-old female infant.
- The tumor exhibited trisomy 15 upon cytogenetic analysis.
Findings:
- Trisomy 15 is a rare chromosomal aberration associated with orbital hemangiopericytoma.
- This report represents the second documented instance of trisomy 15 in infantile HPC.
Implications:
- Highlights a rare genetic finding in infantile orbital hemangiopericytoma.
- May inform future research into the etiology and pathogenesis of HPC.
- Underscores the importance of cytogenetic analysis in pediatric orbital tumors.
Abstract:
We report a case of an orbital hemangiopericytoma (HPC) in a female infant diagnosed at 7 weeks of age. Cytogenetic analysis of the tumor revealed trisomy 15. To the authors' knowledge, this is only the second reported case of this chromosomal aberration being associated with HPC, both cases occurring in infants.
