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The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
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Sonothrombolysis in acute middle cerebral artery stroke
Amira Zaki Dwedar, Samia Ashour, Mahmoud Haroun
1Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Neurology India
|March 11, 2014
Summary
Continuous 2-MHz transcranial Doppler-ultrasound (TCD-US) sonothrombolysis significantly increased mean flow velocity in the middle cerebral artery (MCA) in acute ischemic stroke patients. This therapeutic option shows promise for improving outcomes in MCA occlusion cases.
Area of Science:
- Neurology
- Medical Ultrasound
- Cerebrovascular Diseases
Background:
- Acute ischemic stroke due to middle cerebral artery (MCA) occlusion requires effective recanalization strategies.
- Transcranial Doppler-ultrasound (TCD-US) is a non-invasive tool for monitoring cerebral blood flow.
Purpose of the Study:
- To evaluate the effect of continuous 2-MHz TCD-US sonothrombolysis on recanalization and short-term outcomes in acute ischemic stroke patients with MCA occlusion.
Main Methods:
- 42 patients with acute ischemic stroke due to MCA occlusion were randomized into two groups.
- Group 1 received 1-hour continuous TCD-US sonothrombolysis, while Group 2 did not.
- Mean flow velocity (MFV) in the MCA was measured, and the National Institutes of Health Stroke Scale (NIHSS) assessed clinical outcomes.
Main Results:
- A significant increase in MFV was observed in the TCD-US group compared to the control group at three time points (P < 0.001).
Conclusions:
- Continuous TCD-US sonothrombolysis is a viable therapeutic option for improving outcomes in acute ischemic stroke patients with MCA occlusion.
