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Creatin-kinase elevation after accidental ingestion of almotriptan in an 18-month-old girl

E Castagno1, M Lupica, S Viola

  • 1Department of Pediatrics, University of Turin Regina Margherita Children's Hospital Turin, Italy - roberto.miniero@unicz.it.

Minerva Pediatrica
|March 11, 2014
PubMed

Insights

Accidental almotriptan ingestion in an 18-month-old led to elevated creatine kinase (CK) levels. Prompt hydration normalized CK, with no adverse effects observed in this pediatric migraine medication case.

Area of Science:

  • Pediatric Neurology
  • Clinical Toxicology

Background:

  • Limited data exists on almotriptan's safety and efficacy in young children with migraine.
  • Migraine treatment in early childhood requires careful consideration of potential adverse effects.

Observation:

  • An 18-month-old infant accidentally ingested 6.25 mg of almotriptan (0.48 mg/kg).
  • The child presented without specific symptoms, but investigations revealed elevated serum creatine kinase (CK) levels (527 IU/L).
  • Other biomarkers including transaminases, creatinine, aldolase, myoglobin, and troponin T remained within normal limits.

Findings:

  • Serum CK levels decreased significantly within 65 hours following parenteral rehydration with saline solution.
  • The infant experienced no adverse symptoms during hospitalization or follow-up.
  • This case highlights a potential biochemical change (elevated CK) following almotriptan overdose in a young child.

Implications:

  • This case suggests careful monitoring for muscle enzyme elevations after almotriptan ingestion in young children.
  • Further research is warranted to establish safe dosing and monitor for potential adverse effects of almotriptan in infants and children.
  • Understanding the biochemical impact of accidental overdose is crucial for pediatric migraine management guidelines.

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