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Related Experiment Videos

Altered exocrine pancreatic function in rats treated with nicotine.

M A Dubick1, R Palmer, P P Lau

  • 1Department of Medicine, Veterans Administration Medical Center, Martinez, California 94553.

Toxicology and Applied Pharmacology
|October 1, 1988
PubMed
Summary

Nicotine treatment significantly increased digestive enzyme content and release in rat pancreas. This suggests potential impacts on exocrine pancreatic function in moderate cigarette smokers.

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Toxicology

Background:

  • Exocrine pancreatic function is crucial for digestion.
  • Nicotine is a major component of tobacco products with known systemic effects.

Purpose of the Study:

  • To investigate the impact of nicotine on exocrine pancreatic function in rats.
  • To determine if nicotine affects digestive enzyme levels and secretion.

Main Methods:

  • Adult male Sprague-Dawley rats received nicotine via time-release pellets for 3 weeks.
  • Assessed pancreatic enzyme activities (amylase, trypsin, chymotrypsin), mRNA levels, and enzyme secretion from isolated pancreatic acini.
  • Stimulated enzyme release using CCK-8, secretin, and carbachol.

Main Results:

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  • Nicotine treatment increased pancreatic amylase, trypsin, and chymotrypsin activities by 51%, 29%, and 35%, respectively.
  • Elevated levels of immunoreactive cationic trypsin(ogen) and amylase mRNA were observed in nicotine-treated rats.
  • Basal and stimulated enzyme secretion from pancreatic acini were significantly higher in nicotine-exposed rats.

Conclusions:

  • Nicotine exposure increases digestive enzyme content within the rat pancreas.
  • Nicotine enhances both basal and stimulated exocrine pancreatic secretion.
  • These findings suggest nicotine may alter pancreatic digestive capacity at levels relevant to human smokers.