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Pemphigus-like eruption induced by d-penicillamine and captopril, in the same patient
R Blanken1, H M Doeglas, M C de Jong
1Department of Dermatology, University Hospital Groningen, The Netherlands.
Acta Dermato-Venereologica
|January 1, 1988
Abstract:
A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that both these chemically related drugs might have been responsible for the pemphigus-like eruption in this patient.