[Cerebral dysfunction after coronary artery bypass graft surgery with cardiopulmonary bypass]

Area of Science:

• Neurology
• Cardiology
• Pharmacology

Context:

• Cardiac surgery, particularly with cardiopulmonary bypass, is associated with multifactorial brain alterations.
• Postoperative cerebral dysfunction, including stroke and cognitive impairment, is a recognized complication.

Purpose:

• To investigate the incidence of postoperative cerebral dysfunction after coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass.
• To evaluate the efficacy of the cytoprotective agent Cytoflavin in mitigating deferred cognitive impairment.

Summary:

• Stroke was diagnosed post-CABG surgery with cardiopulmonary bypass.
• Postoperative cognitive dysfunction was more frequent following surgery with cardiopulmonary bypass.
• Preoperative administration of Cytoflavin significantly decreased the severity of deferred cognitive impairment.

Impact:

• The findings highlight the potential for pharmacological neuroprotection in patients undergoing cardiac surgery with cardiopulmonary bypass.
• Cytoflavin demonstrates promise in reducing the neurological sequelae of cardiac surgery.