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Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy

Deniz Bagdas1, Hasret Yucel Ozboluk, Nilufer Cinkilic

  • 11 Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University , Bursa, Turkey .

Journal of Medicinal Food
|March 12, 2014
PubMed

Keywords:
antihyperalgesicantinociceptivechlorogenic aciddiabetesdiabetic neuropathypain

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Diabetic Neuropathy01:22

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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