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Pharmacological approach to wheezing in preschool children

Susanna Esposito1, Nicola Principi

  • 1Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Pediatric High Intensity Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Via Commenda 9, 20122 Milano , Italy +39 02 55032498 ; +39 02 50320206 ; susanna.esposito@unimi.it.

Expert Opinion on Pharmacotherapy
|March 12, 2014
PubMed

Insights

Identifying childhood wheezing phenotypes is key to effective treatment. This review analyzes drugs for preschool wheezing, noting heterogeneity impacts optimal management.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Pharmacology

Background:

  • Wheezing disorders are common in preschool children, posing significant burdens.
  • Identifying phenotypes and risk factors aids in predicting outcomes and guiding prevention.
  • Early identification can ensure tailored and effective therapeutic strategies.

Purpose of the Study:

  • To review current drug treatments for wheezing in preschool children.
  • To discuss treatment outcomes across different wheezing phenotypes.

Main Methods:

  • Literature review of pharmacological interventions for preschool wheezing.
  • Analysis of studies focusing on drug efficacy in various wheezing phenotypes.

Main Results:

  • Various oral and inhaled drugs show theoretical potential for wheezing control.
  • Evidence suggests different responses to treatments based on wheezing phenotypes.

Conclusions:

  • Phenotypic heterogeneity complicates the determination of optimal management for acute preschool wheezing.
  • Further research is needed to establish evidence-based guidelines for managing diverse wheezing phenotypes.
Abstract

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