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Related Experiment Videos

Hepatitis B surface antigen associated nephrotic syndrome.

A T Elidrissy1, M B Abdurrahman, S Ramia

  • 1Department of Paediatrics, College of Medicine, Riyadh, Saudi Arabia.

Annals of Tropical Paediatrics
|September 1, 1988
PubMed
Summary

Hepatitis B virus (HBV) infection may play a role in causing nephrotic syndrome in children. This HBV-associated nephrotic syndrome often has a poor prognosis, with limited response to steroid therapy.

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Area of Science:

  • Pediatric Nephrology
  • Hepatology
  • Virology

Background:

  • Hepatitis B virus (HBV) association with nephrotic syndrome is debated globally.
  • Family members of affected children also showed HBV markers without clinical issues.

Purpose of the Study:

  • To investigate the role of HBV in the pathogenesis of nephrotic syndrome in children.
  • To analyze the clinical presentation, renal pathology, and prognosis of HBV-associated nephrotic syndrome.

Main Methods:

  • Case series of seven nephrotic children with positive hepatitis B markers.
  • Clinical data collection including hematuria, hypertension, and steroid response.
  • Renal biopsy analysis for pathological findings.
  • Long-term follow-up for end-stage renal disease.

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Main Results:

  • Four patients presented with hematuria; three developed hypertension.
  • Only two patients responded to steroid therapy.
  • Renal biopsies revealed membranous nephropathy (3/4) and mesangioproliferative glomerulonephritis (1/4).
  • Four patients progressed to end-stage renal disease.

Conclusions:

  • HBV infection is implicated in the pathogenesis of nephrotic syndrome in this pediatric cohort.
  • HBV-associated nephrotic syndrome in children has a poor prognosis.
  • Early detection and management strategies for HBV in children with nephrotic syndrome are crucial.