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A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

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Dilated cardiomyopathy in a De Brazza's monkey (Cercopithecus neglectus).

Alena Felkai¹, Larry Vogelnest, Suzanne McNabb

¹Petersham, New South Wales, Australia.

Journal of Medical Primatology

|March 12, 2014

Summary

Dilated cardiomyopathy caused heart failure in a De Brazza's monkey. This led to lung complications, highlighting the severe impact of cardiac disease in primates.

Keywords:

decreased myocardial contraction heart failure inappetence non-human primate pleural effusion weight loss

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Area of Science:

Veterinary Cardiology
Primate Medicine
Comparative Pathology

Background:

Cardiomyopathies are observed in various primate species.
Potential causes include infection, nutritional issues, genetics, toxins, or idiopathic factors.
Idiopathic cardiomyopathies are common in primates.

Observation:

A De Brazza's monkey (Cercopithecus neglectus) exhibited symptoms of weight loss and inappetence.
Diagnostic procedures included physical examination, blood work, imaging, and electrocardiography.
The animal presented with clinical signs suggestive of systemic illness.

Findings:

Radiographs and echocardiogram showed pleural effusion, lung collapse, cardiomegaly, and reduced myocardial contractility.
Necropsy confirmed pulmonary infarction secondary to heart failure.
The primary diagnosis was dilated cardiomyopathy.

Implications:

This case underscores the importance of recognizing cardiac disease in non-human primates.
Dilated cardiomyopathy can lead to severe complications such as pulmonary infarction.
Further research into primate cardiomyopathies is warranted for improved diagnostics and treatment.