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Mapping of a DNA sequence that down-regulates the expression of an interferon-induced gene
1Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892.
Abstract:
Recently, an interferon response element (IRE) of approximately 24 bp has been identified by Reich et al. (7) that allows certain genes to be actively transcribed by type I interferons (IFNs). The transcription of several IFN-induced genes in some cells (human fibroblasts and melanoma cells) is inhibited by long-term exposure to IFN. This process requires the synthesis of a new protein(s). Evidence is presented that this same IRE contains the information necessary for long-term IFN treatment to down-regulate the transcription of those genes whose expression it initially activates.
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