Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 2, 2026

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Published on: September 6, 2017

41.6K

Sevoflurane-induced changes in infants' quantifiable electroencephalogram parameters.

Stephen McKeever1, Linda Johnston, Andrew J Davidson

  • 1Department of Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Vic., Australia; Murdoch Childrens Research Institute, Melbourne, Vic., Australia; Melbourne School of Health Sciences, The University of Melbourne, Melbourne, Vic., Australia.

Paediatric Anaesthesia
|March 12, 2014
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychiatric and behavioural sequelae following encephalitis: a systematic review and meta-analysis.

Brain communications·2026
Same author

Academic performance of enrolled nurses in Bachelor of Nursing transition programs: A scoping review.

Nursing outlook·2026
Same author

Perspectives of Children, Parents, and Healthcare Providers on Outcomes after Anesthesia for Surgery: An International Mixed Methods Stakeholder Engagement Study from the Pediatric Perioperative Outcomes Group.

Anesthesiology·2026
Same author

End-of-life education: An explorative study using artificial intelligence simulations in undergraduate nursing.

Nursing outlook·2025
Same author

Global & Community Health: What Did the COVID-19 Pandemic Teach Us About Neurologic Surveillance Approaches, and How Should We Be Better Prepared?

Neurology·2025
Same author

Parents' and nurses' experiences of end-of-life care in intensive care for children: A systematic review.

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses·2025

Amplitude-integrated electroencephalogram (aEEG) is not a reliable measure for anesthesia depth in young children. Spectral Edge Frequency 90% (SEF90) and Bispectral Index (BIS) showed better predictive properties in children over six months old.

Area of Science:

  • Pediatric Anesthesiology
  • Neurophysiology
  • Medical Device Technology

Background:

  • Electroencephalogram (EEG) based anesthesia monitoring shows reduced reliability in infants due to developmental changes in EEG frequencies.
  • Amplitude-integrated EEG (aEEG), a time-domain measure, may offer better utility in pediatric anesthesia depth assessment.

Purpose of the Study:

  • To evaluate the correlation between age-adjusted Minimal Alveolar Concentration (MAC) multiples and aEEG.
  • To assess the predictive performance of aEEG, SEF90, and BIS for anesthesia depth in children under two years old.

Main Methods:

  • A prospective study involving 51 children under two years of age.
  • Simultaneous collection of aEEG, SEF90, and BIS data during sevoflurane anesthesia at 0.75, 1, and 1.25 MAC.
Keywords:
anesthesiaconsciousnesselectroencephalographyinhalationintraoperativemonitoring

More Related Videos

How to Obtain Reliable Visual Event-related Potentials in Newborns
07:39

How to Obtain Reliable Visual Event-related Potentials in Newborns

Published on: October 24, 2019

5.7K
Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
09:29

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

3.0K

Related Experiment Videos

Last Updated: May 2, 2026

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Published on: September 6, 2017

41.6K
How to Obtain Reliable Visual Event-related Potentials in Newborns
07:39

How to Obtain Reliable Visual Event-related Potentials in Newborns

Published on: October 24, 2019

5.7K
Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
09:29

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

3.0K
  • Calculation of Prediction Probability (Pk) and correlation coefficients for each EEG parameter.

    • Main Results:

    • aEEG demonstrated poor predictive power (Pk <0.72) for anesthesia depth across all age groups.
    • SEF90 and BIS showed better predictive properties (Pk >0.81) in children aged 6 months to 2 years.

    Conclusions:

    • Amplitude-integrated EEG (aEEG) is not recommended for monitoring anesthesia depth in young children.
    • SEF90 and BIS are more reliable indicators of anesthesia depth in pediatric patients over six months of age.