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Updated: May 2, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
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Lymphangiosarcoma in 12 dogs: a case series (1998-2013).

K M Curran1, C H C Halsey1,2, D R Worley1,3

  • 1Flint Animal Cancer Center, Colorado State University, Fort Collins, CO, USA.

Veterinary and Comparative Oncology
|March 12, 2014
PubMed
Summary

Lymphangiosarcoma (LAS) in dogs is rare, often presenting as masses. Multimodal therapy, including surgery, radiation, and chemotherapy, showed clinical improvement in canine LAS patients.

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Area of Science:

  • Veterinary Oncology
  • Cancer Biology

Background:

  • Lymphangiosarcoma (LAS) is a rare malignant neoplasm originating from lymphatic endothelium.
  • Limited therapeutic information is available for canine LAS.
  • Canine LAS often presents as masses or swelling in various body regions.

Purpose of the Study:

  • To review therapeutic outcomes for canine lymphangiosarcoma.
  • To evaluate the efficacy of different treatment modalities for canine LAS.
  • To identify factors influencing survival in dogs with LAS.

Main Methods:

  • Retrospective review of canine LAS histopathology diagnoses over 15 years.
  • Analysis of treatment protocols, including palliative care, prednisone, chemotherapy, surgery, and multimodal therapy.
  • Evaluation of survival times and recurrence rates based on treatment received.
Keywords:
PROX-1caninelymphangiosarcomalymphatic endothelial cellsarcoma

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Main Results:

  • Twelve canine cases of LAS were identified.
  • Dogs receiving multimodal therapies, particularly surgery combined with chemotherapy and/or radiation, demonstrated clinical improvement.
  • Survival times varied significantly, with longer durations observed in dogs undergoing aggressive treatment protocols.

Conclusions:

  • Multimodal therapy appears beneficial for managing canine lymphangiosarcoma.
  • Early diagnosis via tissue biopsy is crucial for progressive, edematous lesions of unknown origin.
  • Further research is warranted to optimize treatment strategies for canine LAS.