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Neutrophilic eccrine hidradenitis. Evidence implicating bleomycin as a causative agent
P J Scallan1, A H Kettler, M L Levy
1Department of Dermatology, Baylor College of Medicine, Houston, TX 77030.
Cancer
|December 15, 1988
Summary
Neutrophilic eccrine hidradenitis (NEH), a rare skin condition, can present uniquely in chemotherapy patients. This case highlights hyperpigmented plaques as an unusual manifestation of NEH.
Area of Science:
- Dermatology
- Oncology
Background:
- Neutrophilic eccrine hidradenitis (NEH) is a rare skin condition.
- It is often associated with chemotherapy treatments for various cancers.
Observation:
- A 13-year-old female undergoing chemotherapy for osteosarcoma developed NEH.
- Her clinical presentation was atypical, featuring hyperpigmented plaques rather than the typical purpuric nodules or erythematous plaques.
Findings:
- Histopathological examination revealed necrosis of eccrine structures with a neutrophilic infiltrate, confirming NEH.
- Bleomycin was identified as the most probable causative agent in this patient.
Implications:
- This case underscores the variable clinical presentations of NEH.
- Awareness of these diverse manifestations is crucial for accurate diagnosis and management in patients receiving chemotherapy.