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Prostaglandin E2 modifies SMAD2 and promotes SMAD2-SMAD4 complex formation.

Chen Yang1, Chen Chen2, Andrey Sorokin1

  • 1Division of Nephrology and Kidney Disease Center, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|March 12, 2014
PubMed
Summary

Prostaglandin E2 (PGE2) promotes Smad2-Smad4 complex formation, independent of TGF-β signaling. This suggests PGE2 induces a novel post-translational modification of Smad2, impacting human disease.

Keywords:
Mesangial cellsProstaglandinsSignaling

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