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Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Distance analysis and sequence properties of functional domains in nucleic acids and proteins
1National Cancer Institute, Laboratory of Mathematical Biology, Frederick, MD 21701.
Abstract:
We present a unified algorithm to analyze distances between short oligomers in large collections of nucleic acids and protein sequences (DISTANP). This extended version of DISTAN methodology not only permits analysis of distances between selected pairs of oligomers, but also allows a user to analyze distances between groups of residues (such as acidic and hydrophobic amino acids). This capacity allows differentiation of sequence properties of known functional domains in nucleic acids and proteins.
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