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Fluorescent analog of OSW-1 and its cellular localization
Rika Yamada1, Tomoya Takeshita1, Masato Hiraizumi1
1Tokyo University of Agriculture and Technology, School of Engineering, Koganei-shi, Tokyo 184-8588, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 12, 2014
Abstract:
OSW-1 is a steroidal saponin, which has emerged as an attractive anticancer agent with highly cancer cell selective activity. A fluorescent analog was prepared from the natural product to analyze its cellular uptake and localization. We found that the fluorescent analog is rapidly internalized into cells and is primarily distributed in endoplasmic reticulum and Golgi apparatus.

