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Acantholytic acanthoma.

M H Brownstein1

  • 1Laboratory of Dermatopathology, Port Washington, NY 11050.

Journal of the American Academy of Dermatology
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Acantholytic acanthoma is a newly identified benign skin tumor. Histologic analysis reveals acantholysis as a key feature, distinguishing it from blistering diseases.

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Area of Science:

  • Dermatology
  • Pathology
  • Oncology

Background:

  • Acantholytic acanthoma is a recently identified solitary, benign cutaneous neoplasm.
  • These tumors present clinically as asymptomatic, keratotic papules or nodules.

Purpose of the Study:

  • To describe the clinical and histological features of 31 cases of acantholytic acanthoma.
  • To differentiate acantholytic acanthoma from similar-appearing benign and malignant skin lesions.

Main Methods:

  • Retrospective analysis of 31 cases of acantholytic acanthoma.
  • Histopathological examination of skin biopsy specimens.

Main Results:

  • Patients ranged from 32 to 87 years (median 60), with a 2:1 male-to-female ratio.

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  • Lesions were frequently diagnosed as keratosis and commonly found on the trunk.
  • Histology showed hyperkeratosis, papillomatosis, acanthosis, and prominent acantholysis, mimicking blistering diseases without evidence of them.

    • Conclusions:

    • Acantholytic acanthoma is a distinct benign epidermal tumor characterized by acantholysis.
    • Its histological features resemble those of certain blistering disorders but are unique to this neoplasm.