Related Experiment Video

Updated: May 2, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

5.4K

Association between red blood cell transfusion and bronchopulmonary dysplasia in preterm infants

Zhiqun Zhang1, Xianmei Huang2, Hui Lu1

  • 1Division of Neonatology, Department of Pediatrics, Hangzhou First People's Hospital, Zhejiang, China.

Scientific Reports
|March 12, 2014
PubMed

Insights

Packed red blood cell (PRBC) transfusions in preterm infants are linked to a higher risk of bronchopulmonary dysplasia (BPD). This study found a significant association, suggesting a cautious approach to transfusions is necessary for these vulnerable infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Hematology

Background:

  • Anemia is frequent in preterm infants, often necessitating packed red blood cell (PRBC) transfusions.
  • PRBC transfusions can improve oxygen-carrying capacity but may be associated with organ dysfunction.
  • Bronchopulmonary dysplasia (BPD) is a significant morbidity in preterm infants.

Purpose of the Study:

  • To investigate the association between PRBC transfusion and the incidence of BPD in preterm infants.
  • To compare BPD rates in infants receiving PRBCs before BPD diagnosis versus those not receiving them or receiving them after diagnosis.

Main Methods:

  • Retrospective study of 231 preterm infants (birth weight ≤ 1,500 g or gestational age ≤ 32 weeks) admitted between August 2008 and November 2013.
  • Comparison of BPD incidence between infants receiving PRBC transfusion before BPD diagnosis (Group 1) and those not receiving transfusions or receiving them after BPD diagnosis (Group 2).
  • Statistical analysis, including adjustment for potential risk factors, to determine the odds ratio for BPD.

Main Results:

  • The incidence of BPD was significantly higher in Group 1 (37.2%) compared to Group 2 (2.1%) (P < 0.00001).
  • Adjusted odds ratio for BPD associated with PRBC transfusion before diagnosis was 9.80 (95% CI, 1.70-56.36; P = 0.01).
  • An association was demonstrated between PRBC transfusion and increased BPD rates in preterm infants.

Conclusions:

  • PRBC transfusion administered before the diagnosis of BPD is associated with a significantly increased incidence of BPD in preterm infants.
  • Findings suggest a need for a cautious approach to PRBC transfusion in preterm neonates.
  • Further research may be warranted to elucidate the mechanisms behind this association.

More Related Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

882
Transcutaneous Microcirculatory Imaging in Preterm Neonates06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

7.8K

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.3K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
13.0K
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
3.0K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K
Pneumothorax-I01:26

Pneumothorax-I

A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
2.2K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
5.2K