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Synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids
Dongguk Min1, Minkyu Kim, Jérémy Ricci
1Department of Chemistry, Yonsei University.
Abstract:
The practical synthesis and anticancer activity of novel deoxoartemisinin-glycolipid hybrids, which incorporate two drugs into a single molecule and can impact multiple targets simultaneously are presented. These hybrids exhibited potent in vitro anticancer activity against several human cancer cell lines. The deoxoartemisinin-glycolipid hybrids generally demonstrated better anticancer activity than either artemisinin or daumone alone and cisplatin.
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