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Involvement of Arabidopsis HAC family genes in pleiotropic developmental processes

Chao Li1, Jiang Xu2, Jian Li3

  • 1National Institute of Biological Sciences; Beijing, PR China; Department of Molecular Biology and Biochemistry; University of Massachusetts; Amherst, MA USA.

Plant Signaling & Behavior
|March 12, 2014
PubMed

Insights

Arabidopsis HAC genes regulate plant development. HAC1 is key, with HAC5 and HAC12 assisting, while HAC4 modulates their effects, impacting traits like flowering time.

Area of Science:

  • Plant Molecular Biology
  • Epigenetics
  • Arabidopsis thaliana research

Background:

  • CREB binding protein (CBP)/p300 proteins are crucial regulators of cellular processes via histone and non-histone acetylation.
  • Arabidopsis CBP-type histone acetyltransferase (HAC) family proteins influence flowering time by regulating Flowering Locus C and are involved in ethylene signaling.

Purpose of the Study:

  • To systematically analyze the morphological and developmental phenotypes of all hac mutant combinations.
  • To elucidate the regulatory roles and interactions of HAC family genes in Arabidopsis development.

Main Methods:

  • Generation and analysis of multiple hac mutant combinations in Arabidopsis.
  • Phenotypic characterization including plant size, root development, flower morphology, leaf defects, and flowering time.

Main Results:

  • HAC family genes exhibit ubiquitous regulatory roles in plant development.
  • HAC1 plays a dominant role, synergistically assisted by HAC5 and HAC12.
  • HAC4 partially counteracts the effects of HAC1 and HAC5.

Conclusions:

  • The HAC gene family collectively regulates diverse developmental processes in Arabidopsis.
  • Specific HAC members (HAC1, HAC5, HAC12, HAC4) interact to fine-tune developmental outcomes, particularly flowering time.

Keywords:
CBP/p300HACdevelopmentethylenehistone acetyltransferasesignaling

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