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Promising coagulation factor VIII bypassing strategies for patients with haemophilia A

Xunwei Duan1, Mingqing Tang, Junping Zhang

  • 1aSchool of Biomedical Sciences and Institute of Molecular Medicine, Huaqiao University bEngineering Research Center of Molecular Medicine, Ministry of Education, Fujian, PR China.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|March 12, 2014
PubMed

Haemophilia A is an X-linked recessive monogenic hereditary bleeding disorder caused by a deficiency or functional defect in coagulation factor VIII (FVIII). Typically, only 30% haemophilia A patients are treated with FVIII-specific products successfully. Therefore, other promising clotting factors and FVIII-bypassing factors exhibiting sufficient FVIII-independent activity, low immunogenicity and prolonged half-life are needed to conquer this malady. Here, we will systematically review the current status of the diverse FVIII-bypassing factors for the treatment of FVIII-insensitive haemophilia A patients.

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