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Interferon induction and granulocyte function in patients with viral meningitis
I L Moringlane1, S Einhorn, C Jarstrand
1Karolinska Institute, Roslagstull Hospital, Stockholm, Seden.
Journal of Clinical & Laboratory Immunology
|June 1, 1988
Summary
In viral meningitis, neutrophil phagocytosis is impaired during acute illness, correlating with increased interferon levels. Functionality recovers as interferon decreases, suggesting interferon influences neutrophil impairment in viral infections.
Area of Science:
- Immunology
- Virology
- Cellular Biology
Background:
- Neutrophilic granulocytes play a critical role in the innate immune response.
- Viral meningitis can lead to alterations in immune cell function.
- Interferon (IFN) is a key cytokine involved in antiviral defense.
Purpose of the Study:
- To investigate the phagocytic capacity of neutrophils in patients with acute viral meningitis.
- To assess serum and cerebrospinal fluid interferon levels during viral meningitis.
- To evaluate the activity of 2'-5' oligoadenylate synthetase in peripheral lymphoid cells.
Main Methods:
- Studied 22 patients with acute viral meningitis.
- Assessed neutrophil phagocytosis of yeast particles.
- Measured serum and cerebrospinal fluid interferon levels.
- Quantified 2'-5' oligoadenylate synthetase activity in peripheral lymphoid cells.
Main Results:
- Neutrophil phagocytosis was decreased, while yeast adherence increased during acute viral meningitis.
- Interferon was detected in cerebrospinal fluid.
- 2'-5' oligoadenylate synthetase activity in peripheral lymphoid cells was elevated.
- Phagocytic activity and synthetase activity normalized approximately two months post-onset.
Conclusions:
- Impaired neutrophil function in viral meningitis may be influenced by elevated in vivo interferon levels.
- Interferon may play a regulatory role in neutrophil dysfunction during viral infections.
- Restoration of immune function correlates with decreased interferon levels.