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Hypnotic hiccups.
Robert Daniel Vorona1, Mariana Szklo-Coxe, James Catesby Ware
1Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.
BMJ Case Reports
|March 12, 2014
Summary
Eszopiclone, a sleep medication, may cause intermittent hiccups during sleep. A bed partner
Area of Science:
- Sleep Medicine
- Pharmacology
- Neurology
Background:
- Hiccups are involuntary contractions of the diaphragm.
- Sleep-related hiccups are uncommon but can disrupt sleep quality.
- Hypnotic medications are frequently used for insomnia.
Observation:
- A patient experienced recurrent, self-limited episodes of forceful hiccups exclusively during sleep.
- These hiccups were temporally associated with the use of eszopiclone, a nonbenzodiazepine hypnotic agent.
- The patient's bed partner provided the crucial historical information regarding the hiccups and medication use.
Findings:
- Esopiclone use was identified as a potential iatrogenic cause of sleep-related hiccups.
- The adverse effect was characterized by repetitive, forceful, and self-limited bouts of hiccups during sleep.
- This case highlights a previously under-recognized side effect of eszopiclone.
Implications:
- Clinicians should consider eszopiclone as a potential cause of unexplained sleep-related hiccups.
- Thorough medication history, including input from bed partners, is essential for diagnosing sleep disturbances.
- Further research may be warranted to elucidate the mechanism of eszopiclone-induced hiccups.
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