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Selective attention in Alzheimer's disease: CSF correlates of behavioral impairments
D M Freed1, S Corkin, J H Growdon
1Department of Psychology and Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139.
Neuropsychologia
|January 1, 1988
Abstract:
CSF levels of HVA, 5-HIAA, and free MHPG, the major metabolites of dopamine, serotonin, and norepinephrine respectively, were measured in 22 patients with AD. These 22 patients were also administered tests of picture-recognition and attentional focusing as part of an earlier experiment. A significant association between deficits in attentional focusing and reduced levels of free MHPG in CSF was noted. These results suggest that behavioral measures can identify patients with noradrenergic involvement.